Assessment of Plasma N-Terminal Pro-Brain Natriuretic Peptide and CRP in Patients with Severe Sepsis, Septic Shock and Acute Heart Failure

Background: Increased plasma levels of brain natriuretic peptide (BNP) have been identified as predictors cardiac dysfunction and prognosis in congestive heart failure ischemic disease. In severe sepsis patients, however, no information is available yet about the prognostic value peptides Egyptian patients. Aim: The aim present work to study relationship between amino-terminal pro-BNP, C-reactive protein one hand severity organ mortality on admission other patient with septic shock.Patients methods: This population consisted ninety patients aged >18 years, who were admitted internal medicine department ICU, Kasr El-Aini Hospitals, Cairo University enrolled within 24 hours ICU sepsis, shock, acute decompensated developed while ICU. divided 3 groups, Group I (septic shock), group II (severe sepsis) III (heart failure). Plasma N-Terminal Pro-Brain Natriuretic Peptide CRP measured.Results: There was higher level (69.56 ± 38.01) compared (41.70 25.34) a significant p (0.002). NTproBNP (2809.73 2362.32 pg/ml) (2595.13 1968.39 (789.37 348.01pg/ml) statistically valueConclusion: NT-pro BNP values are increased shock. Values significantly non survivors than survivors. Elevated concentrations serum indicators an risk shock death.